Dopamine Receptor Transcript Localization in Human Brain

The identification of five dopamine receptors in the past decade (12, 15, 19, 61, 63, 64, 67, 70) has led to renewed enthusiasm for the study of the possible role of dopaminergic dysfunction in neuropsychiatric conditions, especially in psychotic disorders and substance abuse. These five dopamine receptors are all members of the superfamily of seven transmembrane domain, G-protein coupled receptors and cluster into D1 and D2like families of receptors. The assignment of a cloned receptor to one of these families was based on shared pharmacological features, second messenger coupling, and conserved structural features among individual receptors.